Prooxidant and antioxidant properties of salicylaldehyde isonicotinoyl hydrazone iron chelators in HepG2 cells
نویسندگان
چکیده
منابع مشابه
The antioxidant effects of a novel iron chelator salicylaldehyde isonicotinoyl hydrazone in the prevention of H O injury in adult
Objective: This study was designed to investigate the cardioprotective effect of the novel lipophilic iron chelator salicylaldehyde ? isonicotinoyl hydrazone (SIH) against the oxidative stress exerted by H O through the production of OH radical via the Fenton reaction 2 2 1 1 and to compare them with those of the hydrophilic iron chelator deferoxamine (DFO) and the Na /H exchange inhibitor meth...
متن کاملStructure-Activity Relationships of Novel Salicylaldehyde Isonicotinoyl Hydrazone (SIH) Analogs: Iron Chelation, Anti-Oxidant and Cytotoxic Properties
Salicylaldehyde isonicotinoyl hydrazone (SIH) is a lipophilic, tridentate iron chelator with marked anti-oxidant and modest cytotoxic activity against neoplastic cells. However, it has poor stability in an aqueous environment due to the rapid hydrolysis of its hydrazone bond. In this study, we synthesized a series of new SIH analogs (based on previously described aromatic ketones with improved ...
متن کاملThe potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents.
Numerous studies have suggested that iron (Fe) chelators such as desferrioxamine (DFO) may be useful antitumor agents (Blatt and Stitely, Cancer Res 47:1749, 1987; Becton and Bryles, Cancer Res 48:7189, 1988). Recent work with several analogues of the lipophilic Fe chelator, pyridoxal isonicotinoyl hydrazone (PIH), indicate that some of these ligands are considerably more efficient than DFO bot...
متن کاملThe potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents II: the mechanism of action of ligands derived from salicylaldehyde benzoyl hydrazone and 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone.
We have recently screened 36 analogues of the lipophilic iron (Fe) chelator, pyridoxal isonicotinoyl hydrazone (PIH), for their antiproliferative effect (Richardson et al, Blood 86:4295, 1995). Of these compounds, 1 chelator derived from salicylaldehyde benzoyl hydrazone (206) and 4 ligands derived from 2-hydroxy-1-naphthylaldehyde benzoyl hydrazone (308, 309, 311, and 315) showed pronounced an...
متن کاملDirect, derivative spectrophotometric determination of micro amounts of Vanadium (V) by 5-bromo salicylaldehyde isonicotinoyl hydrazone
A simple and highly selective spectrophotometric method has been developed for the determination of trace amounts of V (V) using newly synthesized reagent 5-bromo salicylaldehyde isonicotinoyl hydrazone (5BrSAINH) in aqueous DMF medium. Vanadium (V) forms a brown colored soluble complex with 5-BrSAINH in the pH range 1.0-5.0. The complex shows maximum absorbance at 400nm in the pH range 4.5-5.5...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - General Subjects
سال: 2015
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2015.08.005